I've seen a few posts relating to Sylar's role as a watchmaker. This ties in with Moore's Watchmen, for example.
I think there's another more significant reason for Sylar being written as a watchmaker (possibly the same source as Moore's reason for using the watchmaker). The 'Watchmaker analogy' is a counter-argument against evolution, stating that the world (and people in it) are so complex that their very existance proves that a higher power exists, just as the existance of a watch proves there must have been a watchmaker.
'The Blind Watchmaker' by Richard Dawkins is the name of a book which refutes that theory and provides further support of the theory of evolution - clearly a major topic in Heroes. The fact that Sylar is not only a watchmaker, but also wears glasses (not quite blind) ties in with this, and the fact that he stops wearing glasses perhaps indicating his desire to control the evolution process.

